How does ionizing radiation destroy dna?

Ionizing radiation directly affects the structure of DNA by inducing DNA breaks, particularly DSB. Side effects are the generation of reactive oxygen species (ROS) that oxidize proteins and lipids, and also induce various DNA damage, such as the generation of abasic sites and single-stranded breaks (SSB).

How does ionizing radiation destroy dna?

Ionizing radiation directly affects the structure of DNA by inducing DNA breaks, particularly DSB. side effects are the generation of reactive oxygen species (ROS) that oxidize proteins and lipids, and also induce various DNA damage, such as the generation of abasic sites and single-stranded breaks (SSB). Radiation and electrons bombarded by radiation move randomly inside the cell, damaging the various molecules that form it. Chromosomal DNA inside the cell nucleus can also be damaged.

Ionizing radiation, such as gamma rays, x-rays, and radioactive particles, can cause cancer by damaging DNA. However, it is not known how this occurs or how many tumors are caused by radiation damage. Ionizing radiation exists everywhere all the time; however, the exact molecular mechanism between ionizing radiation and cells remains unclear. Atoms in the state of ionization and excitation, or molecules produced by ionizing radiation, are unstable and, thereafter, rapidly transform into free radicals and neutral molecules that result in complex chemical changes.

LDIR, low dose ionizing radiation; HDIR, high dose ionizing radiation; LET, linear energy transfer; SSB, single strand break; DSB, double strand break; ROS, reactive oxygen species. Cell damage caused by ionizing radiation is very complex and has generalities and specificities with respect to the different types, characters and methods of ionizing radiation.

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Tami Arunachalam
Tami Arunachalam

Amateur travel trailblazer. Hipster-friendly food enthusiast. Proud twitter geek. Passionate beer guru. Evil twitter geek. Lifelong coffee maven.

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